For decades, nicotine has been public health enemy number one, inextricably linked to the devastating consequences of combustible tobacco. In the understandable and vital quest to discourage smoking, nicotine itself has often been demonized. However, the advent and proliferation of tobacco harm reduction (THR) products – including vapes, heated tobacco, and oral nicotine pouches – are forcing a more nuanced conversation. These products offer adults a way to consume nicotine, a naturally occurring, non-intoxicating stimulant, without the thousands of harmful chemicals produced by burning tobacco. Yet, a legacy of anti-nicotine messaging persists, potentially harming not only adult smokers seeking safer alternatives but also millions of neurodivergent individuals who may, knowingly or unknowingly, be using nicotine for its cognitive and mood-regulating effects.