A new legislative trend is sweeping across the United States, fundamentally reshaping the landscape for vaping products. So-called Premarket Tobacco Product Application (PMTA) registry bills are gaining traction in numerous states, presented as a means to protect consumers from unregulated products and curb youth vaping. These laws typically restrict legal vape sales to only those products that have either received marketing authorization from the U.S. Food and Drug Administration (FDA) through its rigorous PMTA pathway or are currently undergoing that intensive review process. Virginia recently confirmed its version of such a law, albeit with a one-year enforcement delay, while similar legislation in Iowa awaits the governor’s decision. However, these bills are far from universally praised. Tobacco harm reduction advocates and smaller, independent vape businesses decry them as overly restrictive, arguing they harmfully limit options for adult smokers seeking safer alternatives to cigarettes and effectively hand market dominance to large tobacco companies whose few FDA-authorized vaping products often fit the narrow criteria.